Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs

نویسندگان

  • KI Bhat
  • K Sufeera
  • Sunil Kumar P Chaitanya
چکیده

The reaction of p-bromoanilino acetohydrazide(II) with aromatic aldehydes in alcohol yielded 2-[4-bromo aniline] N-substituted benzylidine hydrazides (IIIa-IIIj), which in presence of yellow mercuric oxide and iodine in DMF, yielded corresponding 4-bromo[(N-5-substituted 1,3,4 oxadiazole-2 -yl)methyl]aniline (IVa-IVj). Structures of the compounds synthesized were confirmed by IR, (1)HNMR and MASS spectroscopic analysis. The newly synthesized compounds were screened for antibacterial, antifungal and anti-inflammatory activities. Some of the compounds showed remarkable antibacterial, antifungal and anti-inflammatory activities.

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عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2011